Evidence, eminence and extrapolation
نویسندگان
چکیده
منابع مشابه
Evidence, eminence and extrapolation
A full independent drug development programme to demonstrate efficacy may not be ethical and/or feasible in small populations such as paediatric populations or orphan indications. Different levels of extrapolation from a larger population to smaller target populations are widely used for supporting decisions in this situation. There are guidance documents in drug regulation, where a weakening o...
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COVER Partial view of the predictive map of high levels of arsenic in groundwater resources in China (blue, low probability; red, high probability; width, 600 kilometers; resolution, 1 square kilometer). Chronic arsenic poisoning from contaminated groundwater is a major health problem in many parts of China. An estimated 19.6 million people are potentially exposed to elevated arsenic concentrat...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2016
ISSN: 0277-6715,1097-0258
DOI: 10.1002/sim.6865